Mathematical Biology Seminar: Maziyar Jalaal
Topic
A model for the controlled release of nano-encapsulated tissue plasminogen activator using shear activation
Speakers
Details
A model is presented for the controlled release of Tissue Plasminogen Activator tPA from nanoparticles, using shear stress as a trigger. The present model resolves blood flow in a partially blocked vessel, motion of micro-scale particles (aggregated nanoparticles), and the subsequent release of nano-particles encapsulating tPA due to shear activation. Assumptions and results will be described and comments made regarding the further development of this class of nano-medicine.