Math Biology Seminar: Gautam I. Menon
Topic
A Computational Model for Chromosome Positioning
Speakers
Details
DNA in the form of chromosomes is packaged by histones, proteins that help to compact the approximately 2m of DNA in our nuclei into a nuclear space of a few microns in extent. The combination of DNA, and the proteins and RNA which bind to it, is chromatin. I will describe recent theoretical work from my group on models for the architecture of chromatin in the mammalian cell nucleus. These models describe chromatin as "active matter", a term which emphasizes the central role of non-equilibrium (energy-consuming) processes, or "activity". Our results address several long-standing questions in nuclear architecture, among them the large-scale territorial organization of chromosomes and their non-trivial positioning patterns, suggesting a simple, yet general, framework within which they may be understood.
Additional Information
Location: ESB 4133
Gautam I. Menon, Institute of Mathematical Sciences, Chennai, India
Gautam I. Menon, Institute of Mathematical Sciences, Chennai, India
This is a Past Event
Event Type
Scientific, Seminar
Date
September 3, 2015
Time
-
Location