Math Biology Seminar: Cole Zmurchok
Topic
Modelling the interplay of cell signalling and cell mechanics
Speakers
Details
Signalling networks of Rho GTPases regulate single and collective cell migration. Mechanical effects, such as membrane tension and cell-cell pulling forces, also play a role in these networks. We couple a 1D ODE model for GTPase signalling within a cell with a simple model of cell mechanics. By coupling GTPase activation to membrane tension or pulling forces, we characterize the possible feedback loops that regulate cell length. We extend the single-cell model to a multicellular group by assuming that cell-cell junctions are responsible for transmitting forces to neighbouring cells. The interplay between cell-cell mechanics and GTPase signalling is responsible for the emergence of coordinated migratory behaviour in the model. This suggests that a core network of mechanical signals and GTPase signalling can organize multicellular migration.
Additional Information
Location: PIMS (ESB 4th floor)
Cole Zmurchok, UBC
Cole Zmurchok, UBC
This is a Past Event
Event Type
Scientific, Seminar
Date
November 23, 2016
Time
-
Location