Math Biology Seminar: Rebeca Cardim Falcão

Understanding the spatial organization and dynamics of receptors at the cell membrane is an important step towards a full mechanistic model of cell activation. Single particle tracking (SPT) is an important experimental technique for analyzing receptor motion and confinement. Briefly, low densities of receptors are labeled and then tracked via video microscopy. In this talk, I am going to show a critical comparison between two different ways of labeling receptors: cyanine dyes or quantum dots, and how they can influence the mobility of B cell receptors. Moreover, I will show some initial analysis of SPT data of labeled pMHC on a supported lipid bilayer, where a T cell is placed on top of it.