Math Biology Seminar: William Holmes

Cellular organization is regulated by a complex network of interactions between cytoskeletal regulators and the cytoskeleton itself. Here I will utilize mathematical modeling discuss how these complex interactions can give rise to a range of morphological cellular behaviors. I’ll discuss 1) how Rho GTPase dynamics give rise to a diverse array of cellular morphologies observed experimentally. 2) How feedback interactions between the cytoskeleton and the proteins responsible for its remodeling influence the dynamics of actin remodeling. 3) How interactions between the extra cellular matrix and Rho GTPase signaling modulate cellular migration. And 4) how feedbacks between GTPase signaling and membrane tension provide a mechanical means for cells to adapt to high concentration signaling environments. Together these investigations paint a picture where Rho GTPases form a signaling hub of cytoskeletal regulation and feedbacks between them and cellular remodeling lead to a diverse array of cellular dynamics.

This will be part of a double-feature, with a pizza lunch for participants.