Math Biology Seminar: Clinton Durney

Epithelial cells organize themselves into tubes for the necessary functions of gas and nutrient transport, and the production and secretion of hormones and enzymes. Such tubes result from the organization and collective motion of a flat sheet of polarized epthelial cells through either a wrapping or budding process. The Drosophila Salivary Gland is one such tube that results from the budding of a 2D placode of cells. Through orchestrated cell movements and cell rearrangements, the nascent tube begins to form. In this talk, we develop a novel 3D-vertex model that allows for the investigation and quantification of the role that cellular mechanics and cellular rearrangements play during this vital morphogenetic process.