Cole Zmurchok

Mathematical modelling is increasingly central to pharmaceutical research and development through the framework of model-informed drug development (MIDD). This talk will introduce the core principles of MIDD and showcase its practical application...

Flocks of birds, schools of fish, and insect swarms provide examples of animals exhibiting collective behaviour. Models of collective behaviour connect mechanisms and behavioural rules to group-level pattern formation. In this presentation, direction...

Using a 3D deformable cell-based simulation, coupled to reaction-diffusion PDEs for chemical concentrations, we model and simulate the polarization, migration, and neuromast deposition in the zebrafish posterior lateral line primordium (PLLP). This...

Signalling networks of Rho GTPases regulate single and collective cell migration. Mechanical effects, such as membrane tension and cell-cell pulling forces, also play a role in these networks. We couple a 1D ODE model for GTPase signalling within a...

Regulators of the actin cytoskeleton such Rho GTPases can modulate forces developed in cells by promoting actomyosin contraction. At the same time, through mechanosensing, tension is known to affect the activity of Rho GTPases. What happens when...

Individually and collectively, cells are organized systems with many interacting parts. Mathematical models allow us to infer behaviour at one level of organization from information at another level. In this talk, I will share two biological...