MITACS Math Biology Seminar 2007
Topic
As the systems approaches are actively adopted in biology, studies for
revealing the link between physical dynamics and corresponding
molecular mechanism will be crucial to better understanding of the
inherent complexity and dynamics of biological phenomena.
Macromolecule diffusion in cells and tissues is important for cell signaling, metabolism and locomotion. Non-invasive or minimally invasive in-vivo photobleaching and single quantum-dot tracking techniques combined with mathematical modeling have been used for quantifying macromolecule diffusion in cells and living tissues, including central nervous system and tumors.
My extensive experience in manipulating the tiny volume of liquids and small biological objects with micro/nanofluidic systems has been stimulating me to think that cells can respond to chemically patterned and topologically textured substrates by sensing the modulated surface forces. More specifically, my current aim is to find the role of membrane tension in spreading and self-propulsion during cell migration by applying fluid dynamics approaches to describing the motion of droplets and thin films on the substrates with chemical or topological patterns.
Interdisciplinary collaborations between engineers and biologists would also lead to continuous advancement in engineering by applying uncovered design principles and intrinsic strategies in biological systems.
Macromolecule diffusion in cells and tissues is important for cell signaling, metabolism and locomotion. Non-invasive or minimally invasive in-vivo photobleaching and single quantum-dot tracking techniques combined with mathematical modeling have been used for quantifying macromolecule diffusion in cells and living tissues, including central nervous system and tumors.
My extensive experience in manipulating the tiny volume of liquids and small biological objects with micro/nanofluidic systems has been stimulating me to think that cells can respond to chemically patterned and topologically textured substrates by sensing the modulated surface forces. More specifically, my current aim is to find the role of membrane tension in spreading and self-propulsion during cell migration by applying fluid dynamics approaches to describing the motion of droplets and thin films on the substrates with chemical or topological patterns.
Interdisciplinary collaborations between engineers and biologists would also lead to continuous advancement in engineering by applying uncovered design principles and intrinsic strategies in biological systems.
Speakers
Additional Information
MITACS Math Biology Seminar 2007
Function Follows Form - Transport Phenomena Coupled with Mechanics in Biological Systems
Function Follows Form - Transport Phenomena Coupled with Mechanics in Biological Systems