Math Biology Seminar: Khanh Dao Duc

The translation of proteins is a key part of the central dogma of biology that underlies life. Thus, unraveling the dynamics of translation and understanding how this process is regulated across scales, systems and species, is fundamental. In light of recent experimental data, I will present theoretical and computational tools, which we developed for the past few years, to study translation at the molecular, mesoscopic (single rNA), and macroscopic levels. By combining methods and models from computational geometry, stochastic analysis and systems biology, with sequencing, Cryo-EM and other experimental data, our results highlight the fundamental and complex role played by the ribosomes in modulating the dynamics of translation and its efficiency, which also leads to many challenging and still open questions.